Link between rapid hearing loss and CJD

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Published on 02 April 2013

Researchers at Henry Ford Hospital believe they have found a link between rapid hearing loss in both ears and the rare but always fatal Creutzfeldt-Jakob Disease, and they say patients should be tested for the disorder.

Creutzfeldt-Jakob Disease, or CJD, is often confused with so-called “mad cow disease,” and though they are in the same family of disorders, are not the same. However, both share such symptoms as impaired thinking, jerky body movements, memory loss and dementia. Once infected with CJD, the brain develops holes, resulting in tissue which resembles a sponge.
The research findings will be presented to a scientific meeting of the American Academy of Neurology in San Diego.

Researchers at the Detroit Hospital encountered a 67-year-old patient who had been progressively losing hearing in both ears for two months and was eventually diagnosed with the disease.

According to Ahmad Riad Ramadan, M.D., a Henry Ford neurologist and lead author, when the patient sought treatment he had no significant medical history and was complaining only of a continuing, rapid loss of hearing in both ears, and tinnitus – a “ringing in the ears” – that is a common side effect of hearing loss.

“This was followed by the kind of cognitive decline that is typical of CJD,” Ramadan said. “During the patient’s hospital stay, he also showed signs of ataxia – a lack of coordination – and myoclonus – a spastic muscle twitch.”

Testing found the presence of a telltale protein, and other conditions, that led to a diagnosis of CJD. Researchers noted that the patient’s hearing never improved and he died a month after seeking treatment.

Ramadan said the researchers’ findings were only the fourth time, based on available literature, that hearing loss such as that found in their patient was recognized as the first symptom of CJD.

Source: Henry Ford Hospital